Three cars are said to have collided at the intersection of Southside Road and East Adam Street.
Photos taken at the scene of the crime show a badly damaged black SUV facing the hill, with one white and one blue hatchback facing in the opposite direction.
Police officers and the Scottish Ambulance Service are already on duty.
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Details of possible injuries are not yet known.
The Scottish Police have been asked for a comment.
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A crash caused Pleasance to close in both directions. (Image credit: Iona Young)